tert-Butyl 5-(bromomethyl)-1H-indazole-1-carboxylate

tert-Butyl 5-(bromomethyl)-1H-indazole-1-carboxylate - Names and Identifiers

Name	1H-Indazole-1-carboxylic acid, 5-(bromomethyl)-, 1,1-dimethylethyl ester
Synonyms	1-Boc-5-broMoMethylindazole 5-(Bromomethyl)-1H-indazole, N1-BOC protected Tert-butyl 5-(bromomethyl)indazole-1-carboxylate tert-Butyl 5-(bromomethyl)-1H-indazole-1-carboxylate 1H-Indazole-1-carboxylic acid, 5-(broMoMethyl)-, 1,1-diMethylethyl ester 1H-Indazole-1-carboxylic acid, 5-(bromomethyl)-, 1,1-dimethylethyl ester tert-Butyl 5-(bromomethyl)-1H-indazole-1-carboxylate, 5-(Bromomethyl)-1-(tert-butoxycarbonyl)-1H-indazole
CAS	209804-25-1

tert-Butyl 5-(bromomethyl)-1H-indazole-1-carboxylate - Physico-chemical Properties

Molecular Formula	C13H15BrN2O2
Molar Mass	311.17
Density	1.41±0.1 g/cm3(Predicted)
Boling Point	400.3±37.0 °C(Predicted)
pKa	-1.84±0.30(Predicted)
Storage Condition	2-8°C(protect from light)

tert-Butyl 5-(bromomethyl)-1H-indazole-1-carboxylate - Introduction

acid, 5-(bromomethyl)-, 1,1-dimethylethyl ester is an organic compound with the molecular formula C10H11BrN2O2, and its structure contains a Boc protective group and a bromomethyl group.

The properties of acid, 5-(bromomethyl)-, 1,1-dimethylethyl ester include: white or white-like solid, soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane (DCM) and the like. It is stable at room temperature, but exposure to strong light should be avoided.

acid, 5-(bromomethyl)-, 1,1-dimethylethyl ester is mainly used as an intermediate in organic synthesis reactions. It can be used to synthesize a variety of indazole drugs and bioactive molecules. Its Boc protecting group can provide certain chemical stability and selectivity, making the synthesis process easier to control.

The preparation method of acid, 5-(bromomethyl)-, 1,1-dimethylethyl ester: usually use 5-bromomethylindazole and N-tert-butoxycarbene acid (Boc-OH) the reaction yielded the product. The reaction conditions may be selected to be carried out in the presence of a hydrocarbylating agent and a base.

Regarding safety information, it should be noted that: acid, 5-(bromomethyl)-, 1,1-dimenthythyester should avoid direct contact with skin and eyes during operation, avoid inhaling dust or gas. Wear appropriate personal protective equipment such as lab gloves, goggles, and face shields during operation. At the same time, sealed and stored in a cool, well-ventilated place to avoid contact with oxidants and strong acids and bases. In case of accidental leakage or accident, corresponding treatment methods should be taken, such as washing the affected area with plenty of water and seeking medical treatment in time. In the use and storage process also need to follow the relevant safety procedures.

Last Update：2024-04-09 21:11:58